Description

9(S)-Hode-D4 is a high-purity, deuterium-labeled derivative of the bioactive lipid mediator 9(S)-HODE, serving as a critical internal standard for precise quantitative analysis. This compound is essential for researchers and quality control laboratories requiring the highest level of accuracy in lipidomics and eicosanoid pathway studies. It is primarily utilized in pharmaceutical R&D, clinical diagnostics, and advanced biochemical research where isotopic dilution techniques are employed.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of endogenous 9(S)-HODE and related oxylipins in complex biological matrices like plasma, serum, and tissue homogenates.
• Biomarker Research: Facilitates studies on oxidative stress, inflammation, and related disease mechanisms by enabling precise measurement of lipid peroxidation products.
• Pharmaceutical Development: Supports drug discovery and pharmacokinetic studies targeting pathways involving linoleic acid metabolites and peroxisome proliferator-activated receptors (PPARs).
• Clinical Diagnostics: Employed in the development and validation of diagnostic assays for conditions correlated with altered oxylipin profiles.
• Metabolomics & Lipidomics: A key reagent in targeted metabolomics workflows to ensure data reliability and reproducibility in high-throughput screening.
• Food & Nutrition Science: Used in research analyzing lipid oxidation in food products and studying the bioavailability of dietary fatty acids.

Basic Information

Product Name	9(S)-Hode-D4
CAS No.	890955-25-6
Molecular Formula	C18H28D4O3
Molecular Weight	~300.45 g/mol
Synonyms	(9S)-9-Hydroxy-10E,12Z-octadecadienoic-9,10,12,13-d4 Acid; 9(S)-HODE-d4; 9S-HODE-d4; (9S)-HODE-d4; 9(S)-Hydroxy-10E,12Z-octadecadienoic-d4 Acid; Deuterated 9(S)-HODE; 9S-Hydroxyoctadecadienoic-d4 Acid
EINECS	Contact for details

Quality Control

Every batch of 9(S)-Hode-D4 is manufactured and analyzed under strict quality management systems to ensure identity, purity, and isotopic enrichment. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and chromatographic data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (Assay)	≥ 90% (by NMR)
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.