Description

6-(2-Trifluoromethoxyphenyl)-Picolinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethoxy-substituted aromatic structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modulation. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation small-molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science: Employed in the research of advanced polymers and organic electronic materials due to its aromatic and fluorinated components.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and cellular pathways.

Basic Information

Product Name	6-(2-Trifluoromethoxyphenyl)-Picolinic Acid
CAS No.	887983-48-4
Molecular Formula	C₁₄H₈F₃NO₃
Molecular Weight	295.21 g/mol
Synonyms	2-(2-(Trifluoromethoxy)phenyl)pyridine-6-carboxylic acid; 6-[2-(Trifluoromethoxy)phenyl]pyridine-2-carboxylic Acid; 2-Pyridinecarboxylic acid, 6-[2-(trifluoromethoxy)phenyl]-; Picolinic acid, 6-(2-trifluoromethoxyphenyl)-; 6-(2-Trifluoromethoxy-phenyl)-pyridine-2-carboxylic acid; 6-(2-(Trifluoromethoxy)phenyl)picolinic acid
EINECS	Contact for details

Quality Control

Our 6-(2-Trifluoromethoxyphenyl)-Picolinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.