Description

6-(2,4-Difluorophenyl)-Picolinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific difluorophenyl and picolinic acid structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation small-molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides where the difluorophenyl moiety enhances biological activity and stability.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Material Science Precursor: Potential use in the synthesis of specialized ligands for catalysts or functional materials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	6-(2,4-Difluorophenyl)-Picolinic Acid
CAS No.	887983-05-3
Molecular Formula	C₁₂H₇F₂NO₂
Molecular Weight	235.19 g/mol
Synonyms	2-Picolinic acid, 6-(2,4-difluorophenyl)-; 6-(2,4-Difluorophenyl)pyridine-2-carboxylic acid; 2,4-Difluoro-6-(2-pyridinyl)benzoic Acid; Picolinic acid, 6-(2,4-difluorophenyl)-; 887983-05-3; 6-(2,4-Difluorophenyl)-2-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-(2,4-Difluorophenyl)-Picolinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.