Description

2-(Carboxymethyl)-5-(Trifluoromethoxy)Toluene, 4-(Trifluoromethoxy)-o-Tolylacetic Acid is a high-value, fluorinated aromatic carboxylic acid derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the unique combination of the trifluoromethoxy group and the acetic acid side chain, which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to innovate new active ingredients with improved performance profiles.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a sophisticated intermediate in the development of fluorinated organic electronic materials for displays and lighting.
• Advanced Polymer Modifier: Employed to introduce fluorine-containing side chains into polymers, altering surface properties, chemical resistance, and durability.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry and material science for structure-activity relationship (SAR) studies and the creation of proprietary compound libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	2-(Carboxymethyl)-5-(Trifluoromethoxy)Toluene, 4-(Trifluoromethoxy)-o-Tolylacetic Acid
CAS No.	886763-11-7
Molecular Formula	C11H9F3O4
Molecular Weight	262.18 g/mol
Synonyms	4-(Trifluoromethoxy)-2-methylphenylacetic acid; 2-Methyl-4-(trifluoromethoxy)phenylacetic acid; 5-(Trifluoromethoxy)-o-tolylacetic acid; [4-(Trifluoromethoxy)-2-methylphenyl]acetic acid; α-(4-Trifluoromethoxy-o-tolyl)acetic acid; 2-(Carboxymethyl)-5-(trifluoromethoxy)toluene; 4-(Trifluoromethoxy)-o-tolylacetic acid; 886763-11-7
EINECS	Contact for details

Quality Control

Our production of 2-(Carboxymethyl)-5-(Trifluoromethoxy)Toluene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF Titration)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.