Description

4-Iodo-3-(Trifluoromethoxy)Benzoic Acid is a high-value, multi-functional aromatic building block featuring both iodine and trifluoromethoxy substituents, making it a critical intermediate for advanced synthesis. Its unique structure enables precise molecular modifications, offering chemists a versatile handle for introducing halogen and fluorine-containing motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients, particularly for applications requiring enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, facilitating challenging cross-coupling reactions.
• Material Science: Employed in the synthesis of advanced organic materials, such as liquid crystals and organic semiconductors, where its electronic properties are advantageous.
• Chemical Biology & Diagnostics: Acts as a probe or labeling agent in bio-conjugation chemistry and the development of molecular imaging agents.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis houses serving the life sciences industry with tailored, complex organic molecules.

Basic Information

Product Name	4-Iodo-3-(Trifluoromethoxy)Benzoic Acid
CAS No.	886762-67-0
Molecular Formula	C8H4F3IO3
Molecular Weight	331.02 g/mol
Synonyms	3-(Trifluoromethoxy)-4-iodobenzoic Acid; 4-Iodo-3-(trifluoromethoxy)benzoic Acid; Benzoic acid, 4-iodo-3-(trifluoromethoxy)-; 886762-67-0; 4-Iodo-α,α,α-trifluoro-m-anisic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Iodo-3-(Trifluoromethoxy)Benzoic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, ensuring full traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.