Description

4-(2,2,2-Trifluoroethoxy)Phenylboronic Acid is a high-value organoboron building block, essential for modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction. Its trifluoroethoxy substituent imparts unique electronic and steric properties, making it a critical intermediate for constructing complex molecules with enhanced metabolic stability and lipophilicity. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology, where the trifluoroethoxy group can improve bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine moiety for enhanced environmental stability and efficacy.
• Liquid Crystal & OLED Material Precursor: Serves as a crucial monomer for creating fluorine-containing polymers and organic electronic materials with specific optoelectronic properties.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a versatile boronic acid partner for forming carbon-carbon bonds between aromatic rings, a fundamental step in medicinal and process chemistry.
• PET (Positron Emission Tomography) Tracer Development: Potential use in the synthesis of fluorine-18 labeled compounds for diagnostic imaging.
• Chemical Biology & Proteomics: Employed as a molecular probe or linker in bioconjugation strategies and activity-based protein profiling.

Basic Information

Product Name	4-(2,2,2-Trifluoroethoxy)Phenylboronic Acid
CAS No.	886536-37-4
Molecular Formula	C8H8BF3O3
Molecular Weight	219.96 g/mol
Synonyms	[4-(2,2,2-Trifluoroethoxy)phenyl]boronic acid; 4-(Trifluoroethoxy)benzeneboronic acid; (4-(2,2,2-Trifluoroethoxy)phenyl)boronic acid; B-[4-(2,2,2-Trifluoroethoxy)phenyl]boronic acid; 4-Trifluoroethoxyphenylboronic Acid; 4-(Trifluoroethoxy)phenylboronic Acid; Boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]-; 886536-37-4
EINECS	Contact for details

Quality Control

Our 4-(2,2,2-Trifluoroethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.