Description

3-(3,4,5-Trifluorophenyl)Propionic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound is critical for introducing the unique physicochemical properties of the trifluoromethylphenyl moiety into target molecules, enhancing their metabolic stability and lipophilicity. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediates: Key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved bioactivity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays (LCDs).
• Organic Electronics: Building block for novel organic semiconductors and charge-transport materials in OLEDs and photovoltaic cells.
• Advanced Material Science: Intermediate in the synthesis of specialty polymers and coatings with enhanced chemical resistance and surface properties.
• Chemical Research & Development: A versatile reagent for medicinal chemistry, facilitating structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	3-(3,4,5-Trifluorophenyl)Propionic Acid
CAS No.	886499-50-9
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	3-(3,4,5-Trifluorophenyl)propanoic acid; 3,4,5-Trifluorobenzenepropanoic Acid; β-(3,4,5-Trifluorophenyl)propionic Acid; 886499-50-9; 3-(Perfluorophenyl)propionic Acid (common misnomer); 3,4,5-Trifluorohydrocinnamic Acid; (3,4,5-Trifluorophenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our 3-(3,4,5-Trifluorophenyl)Propionic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates and ISO 9001 standards for industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.