Description

4-Fluoro-3-(Trifluoromethoxy)Benzoic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for developing compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing their dielectric anisotropy and thermal stability.
• Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with specific chemical resistance, low surface energy, or unique optical properties.
• Organic Synthesis & Catalysis: A versatile reagent in cross-coupling reactions, such as Suzuki and Buchwald-Hartwig couplings, for constructing complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new fluorination methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	4-Fluoro-3-(Trifluoromethoxy)Benzoic Acid
CAS No.	886496-49-7
Molecular Formula	C8H4F4O3
Molecular Weight	224.11 g/mol
Synonyms	4-Fluoro-3-(trifluoromethoxy)benzoic acid; Benzoic acid, 4-fluoro-3-(trifluoromethoxy)-; 3-Trifluoromethoxy-4-fluorobenzoic acid; 4-Fluoro-α,α,α-trifluoro-m-anisic acid; 4-Fluoro-3-trifluoromethoxybenzoic acid; F-TFMBA (abbreviation); 886496-49-7
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Trifluoromethoxy)Benzoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation by IR and NMR, and quantification of key impurities. A Certificate of Analysis (COA) detailing all specifications and test results is supplied with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.