Description

Alisporivir -1 is a potent, non-immunosuppressive cyclophilin inhibitor with significant antiviral and cytoprotective properties. This compound is of high interest for its potential in modulating cellular pathways involved in viral replication and disease pathology. It is primarily utilized by pharmaceutical researchers and developers in the fields of antiviral drug discovery, particularly for hepatitis C and other viral infections, as well as in studies of mitochondrial function and neurodegenerative diseases.

Application

• Antiviral Research: A key investigational agent for inhibiting the replication of hepatitis C virus (HCV) and other viruses by targeting host cyclophilins.
• Drug Discovery & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical and clinical-stage pharmaceutical R&D.
• Mitochondrial Permeability Transition (MPT) Studies: Used in biochemical research to study and inhibit the mitochondrial permeability transition pore, a key event in cell death.
• Neuroprotective Agent Research: Investigated for its potential therapeutic effects in models of neurodegenerative conditions such as Parkinson's and Alzheimer's disease.
• Immunology Research: Employed as a non-immunosuppressive cyclophilin inhibitor to study cyclophilin-mediated immune functions without broad immunosuppression.
• Chemical Biology: A valuable tool compound for probing cyclophilin-dependent cellular processes and signal transduction pathways.

Basic Information

Product Name	Alisporivir -1
CAS No.	882506-05-0
Molecular Formula	C₆₃H₁₁₃N₁₁O₁₂
Molecular Weight	1208.6 g/mol
Synonyms	Debio 025; UNIL-025; Alisporivir; [D-MeAla]³-[EtVal]⁴-CsA; Cyclosporin Derivative Debio 025; Non-Immunosuppressive Cyclosporin A Analogue; Cyclophilin Inhibitor Debio-025
EINECS	Contact for details

Quality Control

Our Alisporivir -1 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced for research use, our quality protocols align with the stringent standards expected in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.