Description

4-Fluoro-3-Nitro-5-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block distinguished by its unique trifluoromethyl and nitro substituents. This compound matters for its critical role in facilitating complex molecular synthesis, particularly in the development of advanced pharmaceuticals and agrochemicals where fluorine incorporation is essential for modulating bioactivity and stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers requiring specific fluorine-based properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Item	Detail
Product Name	4-Fluoro-3-Nitro-5-(Trifluoromethyl)Benzoic Acid
CAS No.	878572-17-9
Molecular Formula	C8H3F4NO4
Molecular Weight	253.11 g/mol
Synonyms	4-Fluoro-3-nitro-5-(trifluoromethyl)benzoic acid; 3-Nitro-4-fluoro-5-(trifluoromethyl)benzoic acid; Benzoic acid, 4-fluoro-3-nitro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-4-fluoro-3-nitrobenzoic acid; 4-Fluoro-3-nitro-α,α,α-trifluoro-m-toluic acid; 878572-17-9 (CAS RN)
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Nitro-5-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.