Description

(11Bs)-8,9,10,11,12,13,14,15-Octahydro-4-Hydroxy-2,6-Bis[2,4,6-Tris(1-Methylethyl)Phenyl]-4-Oxide-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin is a sophisticated organophosphorus compound featuring a sterically hindered, chiral dinaphtho-dioxaphosphepin core. This complex molecular architecture makes it a highly valuable chiral ligand or catalyst precursor in asymmetric synthesis, where it can impart exceptional stereoselectivity. It is primarily needed by research institutions and pharmaceutical R&D departments developing novel active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metals (e.g., Rh, Pd, Ru) in enantioselective hydrogenation, C-C bond formation, and other key transformations.
• Pharmaceutical Intermediate Synthesis: Enabling the production of single-enantiomer intermediates for drugs targeting CNS disorders, cardiovascular diseases, and oncology.
• Advanced Material Research: Potential use in the development of chiral polymers or molecular recognition systems.
• Methodology Development: Serving as a benchmark or novel scaffold in academic and industrial research for new catalytic asymmetric reactions.
• Agrochemical Synthesis: Application in the asymmetric synthesis of chiral active ingredients for herbicides and pesticides.
• Process Chemistry Optimization: Implementation in scale-up routes to improve yield and enantiomeric excess (ee) in commercial fine chemical production.

Basic Information

Product Name	(11Bs)-8,9,10,11,12,13,14,15-Octahydro-4-Hydroxy-2,6-Bis[2,4,6-Tris(1-Methylethyl)Phenyl]-4-Oxide-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin
CAS No.	878111-20-7
Molecular Formula	C48H58O4P
Molecular Weight	721.95 g/mol
Synonyms	(11bS)-4-Hydroxy-2,6-bis(2,4,6-triisopropylphenyl)-4-oxido-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin; H8-BINAP(O) Dioxide Derivative; Sterically Hindered Dioxaphosphepin Ligand; Chiral Dioxaphosphepin Phosphine Oxide; Octahydro-Dinaphtho-Dioxaphosphepin; AT-Phos Ligand Analog; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our high-value chiral chemicals is produced and verified under strict quality management protocols. We employ advanced analytical techniques including Chiral HPLC, 1H/31P/13C NMR, and mass spectrometry to confirm identity, enantiomeric purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C in a dry environment. The compound is moisture-sensitive; containers should be sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.