Description

(S)-1-Cbz-3-n-Boc-Aminopiperidine CAS NO 876379-22-5 is a high-purity, advanced pharmaceutical intermediate featuring dual orthogonal protecting groups on a chiral piperidine scaffold. This compound is critical for enabling efficient, selective synthetic routes in complex molecule assembly, ensuring high yields and stereochemical fidelity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates and bioactive molecules.
• Peptidomimetic Research: Serves as a constrained scaffold for designing and synthesizing peptide analogs with improved metabolic stability and bioavailability.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns, particularly for targets requiring a chiral piperidine moiety.
• Asymmetric Synthesis: Employed in the construction of chiral centers for the production of enantiomerically pure compounds in preclinical and process chemistry.
• Chemical Biology: Utilized as a probe or linker component in the development of chemical tools for studying biological pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	(S)-1-Cbz-3-n-Boc-Aminopiperidine
CAS No.	876379-22-5
Molecular Formula	C19H28N2O4
Molecular Weight	348.44 g/mol
Synonyms	(S)-1-[(Benzyloxy)carbonyl]-3-[(tert-butoxycarbonyl)amino]piperidine; (S)-3-((tert-Butoxycarbonyl)amino)-1-(benzyloxycarbonyl)piperidine; (S)-1-Cbz-3-Boc-aminopiperidine; (S)-N-Boc-1-Cbz-3-aminopiperidine; (S)-1-(Carbobenzyloxy)-3-(N-tert-butoxycarbonyl)aminopiperidine; (S)-1-Cbz-3-(N-Boc-amino)piperidine; (3S)-1-[(Phenylmethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]piperidine; (S)-1-Cbz-3-Boc-NH-piperidine
EINECS	Contact for details

Quality Control

Our (S)-1-Cbz-3-n-Boc-Aminopiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, chiral purity analysis, and spectroscopic identification (NMR, IR). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.