Description

3-(Cyclohexylcarbamoyl)-5-Fluorobenzeneboronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. Its molecular architecture, featuring both a boronic acid pinacol ester precursor and a fluorinated aromatic system, makes it a critical reagent for modern cross-coupling reactions, particularly in Suzuki-Miyaura couplings. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients. It enables the precise construction of complex biaryl structures under mild conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds between aromatic rings, a fundamental reaction in medicinal chemistry and material science.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science & OLED Development: Serves as a precursor for creating novel organic electronic materials and light-emitting compounds.
• Chemical Biology & Probe Synthesis: Utilized for constructing molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific fluorinated biaryl motifs.

Basic Information

Product Name	3-(Cyclohexylcarbamoyl)-5-Fluorobenzeneboronic Acid
CAS No.	874219-42-8
Molecular Formula	C₁₃H₁₇BFNO₃
Molecular Weight	265.09 g/mol
Synonyms	5-Fluoro-3-[(cyclohexylamino)carbonyl]benzeneboronic Acid; [3-(Cyclohexylcarbamoyl)-5-fluorophenyl]boronic Acid; 3-Carbamoyl-5-fluorobenzeneboronic Acid Cyclohexylamide; B-[3-[(Cyclohexylamino)carbonyl]-5-fluorophenyl]boronic Acid; 874219-42-8; 3-Fluoro-5-(cyclohexylaminocarbonyl)phenylboronic Acid
EINECS	Contact for details

Quality Control

Our 3-(Cyclohexylcarbamoyl)-5-Fluorobenzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR (¹H, ¹³C, ¹¹B, ¹⁹F) for structural confirmation, and mass spectrometry to ensure identity and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.