Description

4-Fluoro-3-(Pyrrolidin-1-Ylcarbonyl)Benzeneboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a pyrrolidine amide moiety that can impart specific pharmacological properties. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the presence of the fluorinated aromatic and amide groups.
• Suzuki-Miyaura Cross-Coupling Reagent: Used extensively in palladium-catalyzed reactions to form carbon-carbon bonds, enabling the construction of complex biaryl structures common in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Employed in the development of new herbicides and fungicides, where the boronic acid functionality allows for modular synthesis of diverse compound libraries.
• Material Science: Serves as a monomer or functionalization agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probe Development: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Catalyst Ligand Synthesis: The structure can be modified to create novel ligands for asymmetric catalysis.

Basic Information

Item	Detail
Product Name	4-Fluoro-3-(Pyrrolidin-1-Ylcarbonyl)Benzeneboronic Acid
CAS No.	874219-31-5
Molecular Formula	C11H13BFNO3
Molecular Weight	237.04 g/mol
Synonyms	[4-Fluoro-3-(pyrrolidine-1-carbonyl)phenyl]boronic acid; 3-Carbamoyl-4-fluorobenzeneboronic acid pyrrolidide; 4-Fluoro-3-(N-pyrrolidylcarboxamido)benzeneboronic acid; B-[4-Fluoro-3-(1-pyrrolidinylcarbonyl)phenyl]boronic acid; 874219-31-5; 4-Fluoro-3-pyrrolidin-1-ylcarbonylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Pyrrolidin-1-Ylcarbonyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full characterization data are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.