Description

4-Fluoro-3-(Morpholin-4-Ylcarbonyl)Benzeneboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular architecture, featuring both a boronic acid group and a fluorinated aromatic ring linked to a morpholine carboxamide, makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials. Its precise structure enables the introduction of specific fluorinated motifs, which are key to modulating the bioavailability, metabolic stability, and binding affinity of target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to create novel fluorinated pesticides and herbicides, where the fluorine atom enhances lipophilicity and environmental stability.
• Material Science: Employed in the development of organic electronic materials, such as fluorinated polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of activity-based probes and inhibitors targeting specific enzymes.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel bidentate ligands used in asymmetric catalysis and transition metal complexes.
• Academic & Contract Research: Essential for methodological development in organic synthesis and for exploring new reaction pathways in university and CRO laboratories.

Basic Information

Product Name	4-Fluoro-3-(Morpholin-4-Ylcarbonyl)Benzeneboronic Acid
CAS No.	874219-29-1
Molecular Formula	C11H13BFNO4
Molecular Weight	265.04 g/mol
Synonyms	[4-Fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid; 3-Carbamoyl-4-fluorobenzeneboronic acid morpholide; 4-Fluoro-3-(morpholinocarbonyl)phenylboronic acid; B-[4-Fluoro-3-(4-morpholinylcarbonyl)phenyl]boronic acid; 874219-29-1; 4-Fluoro-3-morpholin-4-ylcarbonylbenzeneboronic acid; AKOS BRN-0769; FT-0698241
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(Morpholin-4-Ylcarbonyl)Benzeneboronic Acid is manufactured and tested under a strict quality management system. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by titration)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.