Description

4-Fluoro-3-(Methylcarbamoyl)Benzeneboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, serving as a versatile intermediate in cross-coupling reactions and as a key precursor for pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boronic acid reagent for forming carbon-carbon bonds, enabling the construction of complex biaryl structures common in drug discovery.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and amide motifs can enhance biological activity and stability.
• Material Science: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors for enzyme studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Product Name	4-Fluoro-3-(Methylcarbamoyl)Benzeneboronic Acid
CAS No.	874219-19-9
Molecular Formula	C8H9BFNO3
Molecular Weight	196.97 g/mol
Synonyms	3-Carbamoyl-4-fluorobenzeneboronic Acid (Methylamide); 4-Fluoro-3-(N-methylcarbamoyl)phenylboronic Acid; (4-Fluoro-3-(methylcarbamoyl)phenyl)boronic Acid; 3-Borono-4-fluoro-N-methylbenzamide; B-[4-Fluoro-3-[(methylamino)carbonyl]phenyl]boronic Acid; 874219-19-9; 4-Fluoro-3-methylcarbamoylbenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Methylcarbamoyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.