Description

Omecamtiv Mecarbil is a novel, selective cardiac myosin activator developed for the treatment of heart failure. This compound represents a significant advancement in cardiovascular pharmacology, offering a unique mechanism of action that directly improves cardiac contractility without increasing intracellular calcium. It is primarily utilized by pharmaceutical research and development organizations, contract manufacturing organizations (CMOs), and academic institutions engaged in cardiology and drug discovery programs.

Application

• Pharmaceutical R&D: Primary application in the research and development of novel therapeutics for systolic heart failure.
• Clinical Trial Material (CTM): Sourced as a high-purity active pharmaceutical ingredient (API) for use in Phase I-III clinical studies.
• Reference Standard: Used as an analytical standard in method development, validation, and quality control testing.
• Mechanistic Studies: Employed in preclinical research to investigate cardiac myosin function and contractility pathways.
• Formulation Development: Serves as the key ingredient in the development of final dosage forms, such as tablets or capsules.
• Process Chemistry: Used for scaling up and optimizing synthetic routes in pilot plant and commercial manufacturing settings.

Basic Information

Product Name	Omecamtiv Mecarbil
CAS No.	873697-71-3
Molecular Formula	C₄₀H₅₀N₈O₆S
Molecular Weight	746.95 g/mol
Synonyms	CK-1827452; AMG 423; (E)-N-(4-(5-((2-(3,4-Dimethoxyphenyl)ethyl)amino)-1,2,4-oxadiazol-3-yl)but-2-en-1-yl)-5-(1-methyl-1H-pyrazol-4-yl)thiophene-2-carboxamide; Omecamtiv mecarbil (USAN); Cardiac myosin activator CK-1827452
EINECS	Contact for details

Quality Control

Our Omecamtiv Mecarbil is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the material should be handled in a low-humidity environment and the container kept sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.