Description

2,3,5-Trifluoro-L-Phenylalanine is a high-purity, non-natural fluorinated amino acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the trifluoromethyl substitution pattern, which is instrumental in modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, protease inhibitors, and positron emission tomography (PET) tracers.

Application

• Pharmaceutical Intermediates: Key synthon for the development of fluorinated drug candidates, especially in oncology and neurology.
• Peptide Chemistry: Incorporation into custom peptides to enhance stability against enzymatic degradation and improve membrane permeability.
• PET (Positron Emission Tomography) Tracer Precursor: Used in the synthesis of F-18 labeled radiopharmaceuticals for diagnostic imaging.
• Agrochemical Research: Building block for novel, fluorinated active ingredients with potentially improved efficacy and environmental profile.
• Material Science: Monomer for specialty polymers and advanced materials where fluorine content is desired for specific surface properties.
• Biochemical Probes: Tool compound for studying enzyme mechanisms and protein-ligand interactions where fluorine acts as a spectroscopic or isotopic label.

Basic Information

Product Name	2,3,5-Trifluoro-L-Phenylalanine
CAS No.	873429-59-5
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	L-2,3,5-Trifluorophenylalanine; (S)-2-Amino-3-(2,3,5-trifluorophenyl)propanoic acid; 2,3,5-Trifluoro-DL-phenylalanine (racemic mixture); F3Phe; 2,3,5-Trifluoro phenylalanine; 2,3,5-Trifluorophenylalanine; NSC 760463; BCP31833
EINECS	Contact for details

Quality Control

Every batch of 2,3,5-Trifluoro-L-Phenylalanine is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We guarantee high chemical and chiral purity, with specifications tailored to meet the stringent requirements of pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) providing results for identity, assay, chiral purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.