Description

3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid is a high-purity fluorinated organic building block with the CAS number 873075-53-7. This compound is a key intermediate valued for its role in synthesizing complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is essential for medicinal chemists and process development scientists working on novel active ingredients that require the introduction of a difluorophenyl alkyne moiety.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and anti-cancer drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and pesticides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for advanced polymers and liquid crystals, where the difluorophenyl group can influence material properties.
• Chemical Biology Probes: Employed in the creation of tagged molecules and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid
CAS No.	873075-53-7
Molecular Formula	C9H4F2O2
Molecular Weight	182.13 g/mol
Synonyms	2,4-Difluorophenylpropiolic Acid; 3-(2,4-Difluorophenyl)propiolic Acid; 2,4-Difluoro-β-propiolactone (common misnomer); Propiolic acid, 3-(2,4-difluorophenyl)-; 873075-53-7; (2,4-Difluorophenyl)propynoic acid
EINECS	Contact for details

Quality Control

Our 3-(2,4-Difluorophenyl)Prop-2-Ynoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.