Description

4-Ethoxy-2,3,5,6-Tetrafluorobenzeneboronic Acid is a high-value organoboron building block, specifically a tetrafluorinated arylboronic acid derivative, essential for modern synthetic chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures under mild conditions. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, leveraging the Suzuki reaction to introduce the tetrafluoroethoxy-substituted aryl moiety into target molecules.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Material Precursor: Serves as a critical monomer for constructing fluorinated aromatic cores in advanced electronic and optoelectronic materials, improving performance and stability.
• Polymer Chemistry: Enables the incorporation of fluorinated aromatic units into specialty polymers, imparting unique properties such as chemical resistance, thermal stability, and low surface energy.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new synthetic routes and creating complex, fluorinated organic architectures.
• Ligand & Catalyst Development: Can be utilized to synthesize novel bidentate or polydentate ligands containing both boronic acid and fluoroaryl groups for catalysis.

Basic Information

Product Name	4-Ethoxy-2,3,5,6-Tetrafluorobenzeneboronic Acid
CAS No.	871125-72-3
Molecular Formula	C8H7BF4O3
Molecular Weight	238.0 g/mol
Synonyms	(4-Ethoxy-2,3,5,6-tetrafluorophenyl)boronic acid; 2,3,5,6-Tetrafluoro-4-ethoxybenzeneboronic acid; 4-Ethoxy-2,3,5,6-tetrafluorophenylboronic acid; B-(4-Ethoxy-2,3,5,6-tetrafluorophenyl)boronic acid; 871125-72-3; 4-Ethoxy-2,3,5,6-tetrafluorophenyl-Boronic Acid; Tetrafluoro-4-ethoxybenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-2,3,5,6-Tetrafluorobenzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for critical coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.