Description

3-(Benzyloxy)-2,6-Difluorobenzeneboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to synthesize complex fluorinated aromatic structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorobenzene motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the benzyloxy and difluoro groups confer specific biological activity.
• Material Science Research: Serves as a monomer or building block for developing advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl systems under mild conditions.
• Chemical Biology & Probe Development: Utilized in creating fluorescent tags, molecular probes, and PET (Positron Emission Tomography) tracer candidates.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-directed synthesis of proprietary compounds.

Basic Information

Item	Details
Product Name	3-(Benzyloxy)-2,6-Difluorobenzeneboronic Acid
CAS No.	870718-07-3
Molecular Formula	C13H11BF2O3
Molecular Weight	264.04 g/mol
Synonyms	2,6-Difluoro-3-(phenylmethoxy)benzeneboronic Acid; (3-(Benzyloxy)-2,6-difluorophenyl)boronic Acid; 3-Benzyloxy-2,6-difluorophenylboronic Acid; B-[3-(Benzyloxy)-2,6-difluorophenyl]boronic Acid; 870718-07-3; AKOS005258065; FT-0776683; NS00023852; BDBM50482895
EINECS	Contact for details

Quality Control

Every batch of 3-(Benzyloxy)-2,6-Difluorobenzeneboronic Acid is manufactured under strict quality management protocols. We guarantee high chemical purity and consistency, supported by comprehensive analytical characterization including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure it meets your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.