Description

2,6-Difluoro-4-Formylphenylboronic Acid is a highly functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a boronic acid moiety on a difluorinated aromatic ring, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for Suzuki-Miyaura cross-coupling reactions to create biaryl structures common in drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the difluoro and formyl groups contribute to biological activity and metabolic stability.
• Material Science Research: Employed in the creation of novel organic electronic materials, ligands for catalysts, and monomers for specialty polymers.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors, leveraging the reactivity of the boronic acid group.
• Ligand Synthesis for Catalysis: Serves as a starting material for synthesizing sophisticated bidentate or tridentate ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	2,6-Difluoro-4-Formylphenylboronic Acid
CAS No.	870717-92-3
Molecular Formula	C7H5BF2O3
Molecular Weight	185.92 g/mol
Synonyms	(4-Formyl-2,6-difluorophenyl)boronic acid; 2,6-Difluoro-4-formylbenzeneboronic acid; 4-Borono-2,6-difluorobenzaldehyde; 2,6-Difluoro-4-carboxaldehydephenylboronic acid; 870717-92-3; (2,6-Difluoro-4-formylphenyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 2,6-Difluoro-4-Formylphenylboronic Acid is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (e.g., DMF, THF, DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.