Description

(S, R)-Reboxetine is a stereoisomeric form of the selective norepinephrine reuptake inhibitor (NRI) used in pharmaceutical research and development. This compound is of significant interest for its role in studying the structure-activity relationships and enantiomeric purity of antidepressant agents. It serves as a critical intermediate or reference standard for pharmaceutical companies, academic institutions, and contract research organizations (CROs) focused on central nervous system (CNS) drug discovery and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a high-purity chemical standard for calibrating analytical instruments (e.g., HPLC, LC-MS) and validating methods for potency and impurity profiling.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthetic pathway for developing novel norepinephrine reuptake inhibitors.
• Pharmacological Research: Employed in in vitro and preclinical studies to investigate the differential biological activity and metabolic pathways of reboxetine stereoisomers.
• Process Chemistry & Development: Utilized in optimizing synthetic routes, scaling up production, and establishing robust purification processes for chiral pharmaceuticals.
• Quality Control & Assurance: Acts as a critical tool for pharmaceutical QC labs to ensure the identity, strength, and purity of batches containing reboxetine-related compounds.

Basic Information

Product Name	(S, R)-Reboxetine
CAS No.	868686-70-8
Molecular Formula	C19H23NO3
Molecular Weight	313.39 g/mol
Synonyms	(±)-Reboxetine; (RS)-Reboxetine; Rac-Reboxetine; Reboxetine Racemate; 2-[(RS)-α-[(2-Ethoxyphenoxy)phenylmethyl]morpholine]; (RS)-2-[(α-(2-Ethoxyphenoxy)benzyl]morpholine; FCE 20124 (racemate)
EINECS	Contact for details

Quality Control

Our (S, R)-Reboxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric composition, NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to support regulatory filings (e.g., FDA, EMA) and GLP/GMP research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (S,R racemic mixture)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.