Description

2-Trifluoromethylquinoline-7-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a quinoline scaffold with a carboxylic acid and a trifluoromethyl group, enabling precise molecular modifications and the introduction of desirable physicochemical properties. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in developing new generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Serves as a building block for advanced organic electronic materials, such as ligands for OLEDs or components for organic semiconductors.
• Ligand Synthesis: Utilized in the preparation of complex chelating ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: An important substrate for studying structure-activity relationships (SAR) and for introducing fluorine atoms into complex molecules to modulate lipophilicity and metabolic stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-Trifluoromethylquinoline-7-Carboxylic Acid
CAS No.	868662-63-9
Molecular Formula	C11H6F3NO2
Molecular Weight	241.17 g/mol
Synonyms	7-Quinolinecarboxylic acid, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)-7-quinolinecarboxylic acid; 2-Trifluoromethyl-7-quinolinecarboxylic acid; 2-Trifluoromethylquinoline-7-carboxylic acid; Quinoline-7-carboxylic acid, 2-trifluoromethyl-; 868662-63-9
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethylquinoline-7-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.