Description

(S)-(4,5-Dimethoxy-1,2-Dihydrocyclobutabenzen-1-Yl)-n-Methylmethanamine is a chiral, advanced pharmaceutical intermediate featuring a unique cyclobutabenzene core structure. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, enabling precise stereochemical control. It is primarily needed by research and development teams in the pharmaceutical and fine chemical industries focused on developing novel therapeutics, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Preclinical Development: Used in the synthesis of candidate compounds for pharmacological evaluation and toxicology studies.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Fine Chemical Synthesis: Acts as a specialized building block for synthesizing complex natural product analogs and other high-value chemicals.

Basic Information

Product Name	(S)-(4,5-Dimethoxy-1,2-Dihydrocyclobutabenzen-1-Yl)-n-Methylmethanamine
CAS No.	866783-12-2
Molecular Formula	C₁₄H₁₉NO₂
Molecular Weight	233.31 g/mol
Synonyms	(1S)-4,5-Dimethoxy-1,2-dihydro-3H-cyclobuta[b]naphthalen-1-yl-N-methylmethanamine; (S)-1-((4,5-Dimethoxy-1,2-dihydrocyclobuta[b]naphthalen-1-yl)methyl)-N-methylmethanamine; (S)-N-Methyl-1-((4,5-dimethoxy-1,2-dihydrocyclobuta[b]naphthalen-1-yl)methyl)methanamine; (S)-4,5-Dimethoxy-1,2-dihydro-3H-cyclobuta[b]naphthalen-1-yl-N-methylmethanamine; (S)-Cyclobutabenzenemethanamine derivative; Chiral Cyclobutabenzene Amine Intermediate
EINECS	Contact for details

Quality Control

Our (S)-(4,5-Dimethoxy-1,2-Dihydrocyclobutabenzen-1-Yl)-n-Methylmethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.