Description

Narlaprevir CAS NO 865466-24-6 is a potent and selective inhibitor of the hepatitis C virus (HCV) NS3/4A serine protease. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the research and development of novel antiviral therapies. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on virology and infectious disease treatment.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of antiviral drugs targeting Hepatitis C Virus (HCV).
• Biochemical Research: A key tool for studying the HCV NS3/4A protease mechanism and viral replication.
• Drug Discovery & Development: Serves as a reference standard and building block in the synthesis of new protease inhibitor candidates.
• Preclinical & Clinical Studies: Used in the manufacturing of drug products for toxicity, pharmacokinetic, and efficacy trials.
• Combinatorial Chemistry: Utilized in libraries for high-throughput screening against viral targets.

Basic Information

Product Name	Narlaprevir
CAS No.	865466-24-6
Molecular Formula	C₄₀H₅₃N₅O₇S
Molecular Weight	731.95 g/mol
Synonyms	SCH 900518; Narlaprevir (SCH 900518); (1R,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(2S,3S)-1-(cyclopropylamino)-3-hydroxy-1-oxobutan-2-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(2S,3S)-1-(cyclopropylamino)-3-hydroxy-1-oxobutan-2-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide
EINECS	Contact for details

Quality Control

Our Narlaprevir is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.