Description

Islatravir is a potent nucleoside reverse transcriptase translocation inhibitor (NRTTI) with the CAS registry number 865363-93-5. This compound is a critical investigational pharmaceutical intermediate in the development of novel antiretroviral therapies. It is primarily required by pharmaceutical R&D departments and contract manufacturing organizations (CMOs) engaged in the synthesis of next-generation treatments for HIV-1 infection.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: Serves as the core building block for the production of the investigational drug Islatravir.
• Antiviral Research & Development: Used as a reference standard and key intermediate in preclinical and clinical studies targeting HIV-1.
• Nucleoside Analogue Development: A vital compound for medicinal chemists exploring novel nucleoside reverse transcriptase inhibitors with improved efficacy and resistance profiles.
• Contract Manufacturing: Supplied to CMOs and CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Biochemical Research: Employed in virology and enzymology studies to understand the mechanism of action of NRTTIs against reverse transcriptase.

Basic Information

Product Name	Islatravir
CAS No.	865363-93-5
Molecular Formula	C12H15FN6O4
Molecular Weight	326.29 g/mol
Synonyms	4'-Ethynyl-2-fluoro-2'-deoxyadenosine; MK-8591; EFdA; (2R,3S,5R)-5-(4-Amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(ethynyl)tetrahydrofuran-3-ol; Islatravir (USAN); 7-[(2R,3S,5R)-3-Hydroxy-5-(2-hydroxyethynyl)tetrahydrofuran-2-yl]-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our Islatravir is manufactured and controlled to meet the stringent requirements for pharmaceutical intermediates. Quality is assured through a comprehensive analytical package including HPLC, NMR, and MS for identity and purity confirmation. We provide full traceability and support regulatory filings with detailed Certificates of Analysis (COA). Specifications are designed to align with ICH Q7 guidelines and current Good Manufacturing Practice (cGMP) standards for investigational products.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.