Description

3,4-Difluoro-5-(Trifluoromethyl)-Phenylboronic Acid is a high-value, multi-fluorinated boronic acid derivative, a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through robust cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, where its unique fluorinated aromatic scaffold imparts desirable metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A key precursor in synthesizing active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the trifluoromethyl and difluoro groups enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: Primarily employed in palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures, a cornerstone of modern medicinal chemistry.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and labeled compounds for diagnostic and biochemical research applications.

Basic Information

Product Name	3,4-Difluoro-5-(Trifluoromethyl)-Phenylboronic Acid
CAS No.	864759-64-8
Molecular Formula	C7H4BF5O2
Molecular Weight	225.91 g/mol
Synonyms	3,4-Difluoro-5-(trifluoromethyl)benzeneboronic acid; (3,4-Difluoro-5-(trifluoromethyl)phenyl)boronic acid; 5-(Trifluoromethyl)-3,4-difluorophenylboronic acid; Boronic acid, B-[3,4-difluoro-5-(trifluoromethyl)phenyl]-; 864759-64-8; 3,4-Difluoro-5-trifluoromethylphenylboronic Acid
EINECS	Contact for details

Quality Control

Every batch of our 3,4-Difluoro-5-(Trifluoromethyl)-Phenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for advanced research and GMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically >97% by HPLC), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.