Description

Zoniporide Hydrochloride Hydrate is a selective sodium-hydrogen exchanger (NHE-1) inhibitor used in pharmaceutical research and development. This compound is a key intermediate and reference standard in the synthesis and study of cardioprotective agents designed to mitigate cellular damage during ischemic events. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery and preclinical studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of zoniporide and related NHE-1 inhibitor drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing.
• Biochemical Research: Employed in in vitro studies to investigate the role of the NHE-1 transporter in cardiac myocytes and other cell types.
• Preclinical Development: Serves as an active pharmaceutical ingredient (API) in formulation studies and animal model research for cardioprotection.
• Mechanistic Studies: A tool compound for exploring ischemia-reperfusion injury pathways and potential therapeutic interventions.

Basic Information

Product Name	Zoniporide Hydrochloride Hydrate
CAS No.	863406-85-3
Molecular Formula	C15H17N5O2 • HCl • xH2O
Molecular Weight	Contact for details
Synonyms	Zoniporide HCl Hydrate; 4-Methyl-6,7-dihydro-4H-thieno[3,2-c]pyran-2-carboxamide, 5-[(4-fluorophenyl)methyl]-2-(1-piperazinyl)-, hydrochloride, hydrate; 1-(5-((4-Fluorobenzyl)thio)-4-methyl-6,7-dihydro-4H-thieno[3,2-c]pyran-2-carbonyl)piperazine hydrochloride hydrate; NHE-1 Inhibitor; CAS 863406-85-3
EINECS	Contact for details

Quality Control

Our Zoniporide Hydrochloride Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the material should be handled in a controlled, low-humidity environment and sealed immediately after use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	As per COA
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	<20 ppm
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.