Description

2-Di-tert-Butylphosphino-3,4,5,6-Tetramethyl-2',4',6'-triisopropylbiphenyl is a highly specialized, sterically hindered phosphine ligand crucial for advanced catalytic processes. Its primary value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental to modern pharmaceutical and fine chemical synthesis. This ligand is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require robust catalysts for constructing complex molecular architectures.

Application

• Catalyst Ligand for Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings for C-N and C-C bond formation.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and scalable production of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring selective coupling steps.
• Material Science Research: Facilitates the creation of conjugated polymers and organic electronic materials through controlled polymerization.
• Process Chemistry & Scale-Up: Provides high activity and stability for transition metal catalysts in pilot plant and commercial manufacturing.
• Academic & Industrial R&D: Serves as a critical tool for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	2-Di-tert-Butylphosphino-3,4,5,6-Tetramethyl-2',4',6'-triisopropylbiphenyl
CAS No.	857356-94-6
Molecular Formula	C31H49P
Molecular Weight	452.70 g/mol
Synonyms	DTBP-TMTP; 2-Di-tert-butylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; cataCXium® Ptb; Di-tert-butyl(3,4,5,6-tetramethyl-2',4',6'-triisopropyl[1,1'-biphenyl]-2-yl)phosphine; JohnPhos derivative; Buchwald ligand; Sterically hindered biarylphosphine ligand; t-BuDavePhos (common misnomer, related structure)
EINECS	Contact for details

Quality Control

Every batch of our phosphine ligands is produced and tested under strict quality management to ensure consistency and performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality systems support compliance with cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. Due to its sensitivity to oxidation and moisture, the container should only be opened in a controlled, dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.