Description

2-Dicyclohexylphosphino-2',4',6'-Triisopropylbiphenyl is a specialized, high-value organophosphorus ligand widely used in transition metal catalysis. This compound matters for its exceptional electron-donating properties and steric bulk, which are critical for enabling challenging cross-coupling reactions with high efficiency and selectivity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for catalyst development and fine chemical synthesis.

Application

• As a key ligand in Buchwald-Hartwig amination reactions for C-N bond formation.
• As a crucial component in Suzuki-Miyaura cross-coupling catalysts for C-C bond construction.
• For catalyst development in pharmaceutical intermediate synthesis.
• In academic and industrial R&D for exploring new catalytic transformations.
• For the preparation of specialty fine chemicals and complex organic molecules.
• In process chemistry optimization for scale-up and manufacturing.

Basic Information

Product Name	2-Dicyclohexylphosphino-2',4',6'-Triisopropylbiphenyl
CAS No.	854045-94-6
Molecular Formula	C36H55P
Molecular Weight	518.80 g/mol
Synonyms	XPhos; 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl; XPhos Ligand; Dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine; XPhos Pd G3; DavePhos; Biarylphosphine Ligand; Buchwald Ligand
EINECS	Contact for details

Quality Control

Our production of 2-Dicyclohexylphosphino-2',4',6'-Triisopropylbiphenyl (XPhos) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive catalytic applications. Each lot is characterized by advanced analytical techniques, including NMR and HPLC, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at room temperature (15-25°C) in a cool, dry place. Due to its sensitivity to oxidation, containers should be flushed with inert gas after each opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.