Description

(-)-6,6'-{[(1S,3S)-1,3-Dimethyl-1,3-Propanediyl]Bis(Oxy)}Bis[4,8-Bis(T-Butyl)-2,10-Dimethoxy-Bibenzo[D,F][1,3,2]Dioxaphosphepin],Min.95%(S,S)-Chiraphite is a high-purity, chiral phosphite ligand, specifically the (S,S)-enantiomer, designed for asymmetric synthesis. This compound is critically important for enabling highly enantioselective transformations in the synthesis of complex pharmaceutical intermediates and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require precise stereochemical control.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metal catalysts (e.g., Rh, Pd, Ir) in enantioselective hydrogenation, hydroformylation, and C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: For the production of single-enantiomer active pharmaceutical ingredients (APIs) where high optical purity is mandated.
• Agrochemical Research: In the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Methodology Development: Used in academic and industrial research labs to develop new catalytic asymmetric methodologies.
• Fine Chemical Production: For the commercial-scale manufacture of specialty flavors, fragrances, and electronic chemicals requiring specific chirality.

Basic Information

Product Name	(-)-6,6'-{[(1S,3S)-1,3-Dimethyl-1,3-Propanediyl]Bis(Oxy)}Bis[4,8-Bis(T-Butyl)-2,10-Dimethoxy-Bibenzo[D,F][1,3,2]Dioxaphosphepin],Min.95%(S,S)-Chiraphite
CAS No.	852042-07-0
Molecular Formula	C58H76O10P2
Molecular Weight	995.16 g/mol
Synonyms	(S,S)-Chiraphite; (S,S)-Chiraphos Analogue; (S,S)-TADDOL-derived Phosphite Ligand; (-)-6,6'-[(1S,3S)-1,3-Dimethyl-1,3-propanediylbis(oxy)]bis[4,8-bis(1,1-dimethylethyl)-2,10-dimethoxydibenzo[d,f][1,3,2]dioxaphosphepin]; Chiraphite Ligand; (S,S)-Bisphosphite Ligand; CAS 852042-07-0
EINECS	Contact for details

Quality Control

Our (S,S)-Chiraphite ligand is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analysis including HPLC for chiral purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and production needs with material suitable for use under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 95%
Chiral Purity (HPLC)	Min. 99% ee (S,S)
Water Content (KF)	Max. 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.