Description

Umirolimus CAS NO 851536-75-9 is a potent and selective mTOR (mammalian target of rapamycin) inhibitor, representing a significant advancement in targeted therapeutic agents. This compound is critical for researchers and developers in the pharmaceutical industry due to its specific mechanism of action, which is essential for studying and treating conditions related to abnormal cell proliferation. It is primarily utilized in advanced pharmaceutical research, preclinical development, and as a key reference standard for analytical purposes.

Application

• Pharmaceutical Research & Development: Serves as a critical active pharmaceutical ingredient (API) and reference standard in the development of novel mTOR-targeted therapies.
• Oncology Research: Used extensively in in vitro and in vivo studies to investigate pathways involved in tumor growth and angiogenesis.
• Immunosuppressant Studies: Applied in research focused on modulating immune responses, particularly in transplant medicine and autoimmune disease models.
• Biochemical Assay Development: Employed as a precise tool compound to validate assays and screen for new compounds targeting the mTOR pathway.
• Metabolic Disorder Research: Utilized in studies exploring the role of mTOR in metabolic signaling and related disorders.
• Academic & Institutional Research: A key reagent for fundamental biological research in cell signaling and molecular biology laboratories worldwide.

Basic Information

Product Name	Umirolimus
CAS No.	851536-75-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Umirolimus; 40-O-(2-Hydroxyethyl)-rapamycin; AP23573; Ridaforolimus; MK-8669; Deforolimus; mTOR Inhibitor AP23573; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
EINECS	Contact for details

Quality Control

Our Umirolimus is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.