Description

Danoprevir is a potent and selective inhibitor of the hepatitis C virus (HCV) NS3/4A serine protease, a key enzyme essential for viral replication. This high-purity pharmaceutical intermediate is critical for research and development programs focused on next-generation antiviral therapies. It is primarily utilized by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in antiviral drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced antiviral active pharmaceutical ingredients (APIs).
• Antiviral Research: Used as a reference standard and biological probe in virology studies to investigate HCV protease function and inhibition mechanisms.
• Drug Discovery & Development: Integral to medicinal chemistry programs aimed at optimizing protease inhibitor scaffolds and developing novel therapeutic candidates.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for GMP manufacturing.
• Analytical Method Development: Used as a high-purity standard for establishing and validating HPLC, LC-MS, and other analytical methods for quality control.

Basic Information

Product Name	Danoprevir
CAS No.	850876-88-9
Molecular Formula	C₃₅H₄₆F₂N₆O₉
Molecular Weight	732.78 g/mol
Synonyms	ITMN-191; R7227; Danoprevir sodium; (1R,2S,5S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[[5-methyl-6-(2-methyl-2-propanyl)-3-pyridinyl]carbonyl]amino]-1-oxo-3-[(3S)-2-oxo-3-pyrrolidinyl]propyl]-3-[(2S)-2-[[7-methoxy-2-(4-morpholinyl)-4-quinolinyl]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; HCV NS3/4A Protease Inhibitor ITMN-191
EINECS	Contact for details

Quality Control

Our Danoprevir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.