Description

3-Fluoro-5-(2,2,2-trifluoroethoxy)benzeneboronic acid is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is critically needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated biaryl and heterobiaryl scaffolds in drug discovery programs, particularly for CNS and oncology targets.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the fluorine and trifluoroethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores in electronic and optoelectronic materials, improving charge transport and emission properties.
• Cross-Coupling Reactions (Suzuki-Miyaura): Primarily employed as a boronic acid coupling partner with various aryl/heteroaryl halides to form carbon-carbon bonds under palladium catalysis.
• Chemical Biology & Probe Development: Utilized for labeling and modifying biomolecules or for creating fluorinated probes used in imaging and diagnostic assays.
• Polymer & Specialty Chemical Modification: Incorporated into polymer backbones or used to functionalize surfaces to impart specific chemical resistance or low surface energy characteristics.

Basic Information

Product Name	3-Fluoro-5-(2,2,2-trifluoroethoxy)benzeneboronic Acid
CAS No.	850589-55-8
Molecular Formula	C8H7BF4O3
Molecular Weight	237.95 g/mol
Synonyms	[3-Fluoro-5-(2,2,2-trifluoroethoxy)phenyl]boronic acid; (3-Fluoro-5-(2,2,2-trifluoroethoxy)phenyl)boronic acid; 3-Fluoro-5-(2,2,2-trifluoroethoxy)phenylboronic acid; Boronic acid, B-[3-fluoro-5-(2,2,2-trifluoroethoxy)phenyl]-; 850589-55-8; 3-Fluoro-5-(trifluoroethoxy)benzeneboronic acid; 3-Fluoro-5-(2,2,2-trifluoroethoxy)benzeneboronic acid pinacol ester (related ester)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(2,2,2-trifluoroethoxy)benzeneboronic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with full analytical data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.