Description

2-Aminomethyl-4-Fluorophenylboronic Acid, HCl is a specialized organoboron building block of significant importance in modern synthetic chemistry. This compound is valued for its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a primary amine group for further derivatization. It is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of novel active compounds and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds in the construction of complex biaryl and heterobiaryl structures.
• Peptide Mimetics & Conjugation: The aminomethyl group enables its use in creating peptide isosteres or for conjugation to other molecules via amide bond formation.
• Agrochemical Research: Employed in the discovery and development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Used in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its rigid, fluorinated aromatic core.
• Chemical Biology Probes: Facilitates the creation of fluorescent tags and molecular probes for studying biological processes and enzyme activity.

Basic Information

Product Name	2-Aminomethyl-4-Fluorophenylboronic Acid, HCl
CAS No.	850568-02-4
Molecular Formula	C7H10BClFNO2
Molecular Weight	205.42 g/mol
Synonyms	(4-Fluoro-2-(aminomethyl)phenyl)boronic acid hydrochloride; 2-(Aminomethyl)-4-fluorobenzeneboronic acid hydrochloride; 4-Fluoro-2-(aminomethyl)benzeneboronic acid HCl; B-(4-Fluoro-2-(aminomethyl)phenyl)boronic acid hydrochloride; 850568-02-4; 2-Aminomethyl-4-fluorophenylboronic acid hydrochloride salt; (2-Aminomethyl-4-fluorophenyl)boronic acid HCl
EINECS	Contact for details

Quality Control

Our 2-Aminomethyl-4-Fluorophenylboronic Acid, HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for critical synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.