Description

2-Bromomethyl-4-Fluorophenylboronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block used in advanced synthetic chemistry. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the creation of novel herbicides and fungicides with enhanced activity and selectivity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, via cross-coupling polymerization.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized to create fluorinated probes for studying protein-ligand interactions and metabolic pathways.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Bromomethyl-4-Fluorophenylboronic Acid Pinacol Ester
CAS No.	850567-57-6
Molecular Formula	C₁₃H₁₇BBrFO₂
Molecular Weight	315.99 g/mol
Synonyms	4-Fluoro-2-(bromomethyl)phenylboronic acid pinacol ester; (4-Fluoro-2-(bromomethyl)phenyl)boronic acid pinacol ester; 2-Bromo-1-(4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methane; 850567-57-6; B-(4-Fluoro-2-(bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(Bromomethyl)-4-fluorobenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-Bromomethyl-4-Fluorophenylboronic Acid Pinacol Ester is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.