Description

4,6-Difluoronicotinic Acid is a high-value fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in introducing the difluoropyridine moiety, a key structural feature that can enhance the metabolic stability, bioavailability, and binding affinity of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, including potential kinase inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the difluoropyridine unit is required.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic materials and liquid crystals.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom chemical synthesis services catering to R&D demands.
• Academic Research: Used in universities and institutes for studying fluorination effects and heterocyclic chemistry.

Basic Information

Product Name	4,6-Difluoronicotinic Acid
CAS No.	849937-91-3
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	4,6-Difluoropyridine-3-carboxylic Acid; 3-Pyridinecarboxylic acid, 4,6-difluoro-; Nicotinic acid, 4,6-difluoro-; 4,6-Difluoro-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4,6-Difluoronicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.