Description

4,6-Difluoro-Pyridine-2-Carboxylic Acid is a high-value fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring carboxylic acid and fluorine substituents, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials for electronic applications.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological systems.

Basic Information

Product Name	4,6-Difluoro-Pyridine-2-Carboxylic Acid
CAS No.	849937-89-9
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	2,4-Difluoropyridine-6-carboxylic Acid; 4,6-Difluoropicolinic Acid; 4,6-Difluoro-2-pyridinecarboxylic Acid; 2-Carboxy-4,6-difluoropyridine; 4,6-Difluoropyridine-2-carboxylate; Picolinic acid, 4,6-difluoro-
EINECS	Contact for details

Quality Control

Our 4,6-Difluoro-Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if opened.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.