Description

(R)-Bupropion Hydrochloride is the single enantiomer form of the widely used antidepressant and smoking cessation aid bupropion. This high-purity chiral intermediate is critical for pharmaceutical research and development focused on stereoselective activity and reduced side-effect profiles. It is primarily utilized by advanced pharmaceutical manufacturers and R&D laboratories for the synthesis of novel enantiopure therapeutics and for detailed pharmacological studies.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of enantiomerically pure (R)-bupropion-based pharmaceuticals.
• Pharmacological Research: Used in preclinical and clinical studies to investigate the distinct biological activity, metabolism, and pharmacokinetics of the (R)-enantiomer.
• Process Development & Optimization: Serves as a reference standard and starting material for developing and scaling up asymmetric synthesis routes.
• Analytical Standard: High-purity material for use as a reference standard in HPLC, LC-MS, and chiral assay methods for quality control.
• Formulation Development: Employed in the development of novel drug delivery systems and dosage forms targeting specific enantiomeric effects.

Basic Information

Product Name	(R)-Bupropion Hydrochloride
CAS No.	849797-12-2
Molecular Formula	C13H19ClNO
Molecular Weight	240.75 g/mol
Synonyms	(2R)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one hydrochloride; (R)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride; (R)-Bupropion HCl; (R)-Amfebutamone Hydrochloride; (R)-ZYBAN; (R)-Wellbutrin; BW 323U91 (R-enantiomer); (R)-2-(tert-Butylamino)-3'-chloropropiophenone hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Bupropion Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤1.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.