Description

Benzoic Acid, 2-Amino-5-(Trifluoromethyl)-, Hydrochloride is a high-purity, trifluoromethyl-substituted aniline derivative, specifically the hydrochloride salt form, offering enhanced stability and handling properties for advanced chemical synthesis. This compound is a critical building block in pharmaceutical and agrochemical research, valued for its unique combination of an aromatic amine and a trifluoromethyl group, which can significantly alter the biological activity and metabolic stability of target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and fluorescent tags for biochemical and diagnostic applications.

Basic Information

Product Name	Benzoic Acid, 2-Amino-5-(Trifluoromethyl)-, Hydrochloride
CAS No.	845797-42-4
Molecular Formula	C8H7F3NO2 • HCl
Molecular Weight	241.60 (Free base) / 278.06 (HCl salt)
Synonyms	2-Amino-5-(trifluoromethyl)benzoic acid hydrochloride; 5-(Trifluoromethyl)anthranilic acid hydrochloride; 2-Amino-α,α,α-trifluoro-p-toluic acid hydrochloride; 2-Amino-5-trifluoromethylbenzoic acid HCl; 5-Trifluoromethylanthranilic acid hydrochloride; 2-Carboxy-4-(trifluoromethyl)aniline hydrochloride; Anthranilic acid, 5-(trifluoromethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 2-Amino-5-(Trifluoromethyl)-, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.