Description

Ethyl 3-Chloro-5-Fluorobenzoylformate is a high-purity fluorinated and chlorinated aromatic ester, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular structure, featuring both halogen substituents, makes it a versatile building block for constructing complex pharmacophores and agrochemical active ingredients. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries seeking to introduce specific halogenated motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of monomers and functionalized aromatic compounds for advanced polymers and liquid crystals.
• Custom Synthesis and Contract Manufacturing: A valuable substrate for fine chemical companies offering bespoke synthesis and scale-up services for client-specific molecules.

Basic Information

Product Name	Ethyl 3-Chloro-5-Fluorobenzoylformate
CAS No.	845790-57-0
Molecular Formula	C10H8ClFO3
Molecular Weight	230.62 g/mol
Synonyms	Ethyl 3-Chloro-5-fluorobenzoylformate; Ethyl (3-Chloro-5-fluorophenyl)(oxo)acetate; 3-Chloro-5-fluorobenzoylformic Acid Ethyl Ester; Ethyl 3-Chloro-5-fluoro-α-oxobenzeneacetate; α-Oxo-3-chloro-5-fluorobenzeneacetic Acid Ethyl Ester; Ethyl 2-Oxo-2-(3-chloro-5-fluorophenyl)acetate; (3-Chloro-5-fluorobenzoyl)formic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-Chloro-5-Fluorobenzoylformate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high standards, including cGMP intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.