Description

Ethyl 4-Chloro-3-Fluorobenzoylformate is a high-purity, multifunctional chemical intermediate prized for its unique halogenated benzoylformate structure. This compound matters for its critical role in facilitating complex synthetic pathways, particularly in the development of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific functional groups into complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the chloro and fluoro substituents contribute to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its aromatic and ester functionalities.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects requiring precise halogenated aromatic esters.
• Academic and R&D Laboratories: Utilized in methodological research for new carbon-carbon bond forming reactions and ester transformations.

Basic Information

Product Name	Ethyl 4-Chloro-3-Fluorobenzoylformate
CAS No.	845790-56-9
Molecular Formula	C10H8ClFO3
Molecular Weight	230.62 g/mol
Synonyms	Ethyl 4-Chloro-3-fluorobenzoylformate; Ethyl (4-Chloro-3-fluorophenyl)(oxo)acetate; 4-Chloro-3-fluorobenzoylformic Acid Ethyl Ester; α-Oxo-4-chloro-3-fluorobenzeneacetic Acid Ethyl Ester; Ethyl 2-Oxo-2-(4-chloro-3-fluorophenyl)acetate; Ethyl 4-Chloro-3-fluoro-α-oxobenzeneacetate; 845790-56-9; (4-Chloro-3-fluorophenyl)(oxo)acetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-3-Fluorobenzoylformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.