Description

(R)-n-Boc-1,2,3,4-Tetrahydro-3-Isoquinolinylmethanol is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic utility. Its core value lies in providing a stereochemically defined scaffold for constructing complex molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries engaged in the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates targeting neurological and cardiovascular disorders.
• Asymmetric Synthesis: Used as a precursor for constructing complex, enantiomerically pure molecules in academic and industrial research.
• Medicinal Chemistry Research: Serves as a versatile building block for creating focused libraries and exploring structure-activity relationships (SAR).
• Peptidomimetics Development: The isoquinoline structure makes it valuable for designing and synthesizing peptide analogs and enzyme inhibitors.
• Catalyst and Ligand Preparation: Can be utilized to develop novel chiral catalysts or ligands for asymmetric transformations.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(R)-n-Boc-1,2,3,4-Tetrahydro-3-Isoquinolinylmethanol
CAS No.	845543-81-9
Molecular Formula	C15H21NO3
Molecular Weight	263.33 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydro-3-(hydroxymethyl)isoquinoline-1-carboxylic acid tert-butyl ester; (R)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-methanol; (R)-tert-Butyl 3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; (R)-1-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinemethanol; (R)-Boc-THIQ-CH2OH; (R)-N-Boc-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (R)-n-Boc-1,2,3,4-Tetrahydro-3-Isoquinolinylmethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.