Description

(R)-n-(3,4-Dimethoxybenzylidene)-2-Methylpropane-2-Sulfinamide is a high-purity chiral sulfinamide compound, widely recognized as an essential chiral auxiliary and ligand in asymmetric synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, offering researchers and manufacturers precise control over reaction outcomes. This advanced intermediate is critically needed by pharmaceutical R&D laboratories and fine chemical producers for the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and other high-value specialty chemicals.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Employed for the enantioselective addition of nucleophiles to imines (Ellman's sulfinamide chemistry), a key step in synthesizing chiral amines.
• Pharmaceutical Intermediate: Used in the research and production of enantiomerically pure drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Ligand for Catalysis: Can serve as a precursor or component in chiral ligands for transition metal-catalyzed asymmetric transformations.
• Agrochemical Synthesis: Applied in the development of chiral herbicides, fungicides, and pesticides where specific stereochemistry is required for optimal activity.
• Academic & Process Chemistry Research: A valuable tool for methodological development and scaling up stereoselective synthetic routes in academic and industrial settings.

Basic Information

Product Name	(R)-n-(3,4-Dimethoxybenzylidene)-2-Methylpropane-2-Sulfinamide
CAS No.	820231-38-7
Molecular Formula	C₁₃H₁₉NO₃S
Molecular Weight	269.36 g/mol
Synonyms	(R)-N-(3,4-Dimethoxybenzylidene)-2-methylpropane-2-sulfinamide; (R)-tert-Butanesulfinamide, N-[(3,4-dimethoxyphenyl)methylene]-; (R)-p-Toluenesulfinamide derivative; (R)-Ellman's Sulfinamide Derivative; (R)-N-(3,4-Dimethoxybenzylidene)-tert-butanesulfinamide; Chiral Sulfinyl Imine; (R)-2-Methyl-N-[(3,4-dimethoxyphenyl)methylidene]propane-2-sulfinamide
EINECS	Contact for details

Quality Control

Our (R)-n-(3,4-Dimethoxybenzylidene)-2-Methylpropane-2-Sulfinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for sensitive asymmetric synthesis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which may affect performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.