Description

(2',6'-Dimethoxy-[1,1'-Biphenyl]-2-Yl)Diphenylphosphine CAS NO 819867-24-8 is a specialized, sterically hindered monodentate phosphine ligand with a biphenyl backbone. This compound is valued for its ability to modulate the electronic and steric environment of transition metal catalysts, significantly impacting reaction rates and selectivity in cross-coupling and other catalytic processes. It is an essential research and development tool for synthetic organic chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Catalyst Ligand in Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed C-C and C-N bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective construction of complex molecular architectures for active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring precise synthetic pathways.
• Material Science & OLED Development: Facilitates the synthesis of conjugated organic molecules for electronic materials and light-emitting devices.
• Asymmetric Catalysis: Employed in the development of chiral catalysts for the production of enantiomerically pure compounds.
• Academic & Industrial R&D: Serves as a critical reagent for methodology development and exploration of new catalytic transformations in laboratory settings.

Basic Information

Product Name	(2',6'-Dimethoxy-[1,1'-Biphenyl]-2-Yl)Diphenylphosphine
CAS No.	819867-24-8
Molecular Formula	C32H27O2P
Molecular Weight	474.53 g/mol
Synonyms	(2,6-Dimethoxybiphenyl-2-yl)diphenylphosphine; 2-(Diphenylphosphino)-2',6'-dimethoxybiphenyl; DavePhos; AlPhos; (2',6'-Dimethoxybiphenyl-2-yl)diphenylphosphine; Biphenyl-based phosphine ligand; SPhos analogue
EINECS	Contact for details

Quality Control

Our production of (2',6'-Dimethoxy-[1,1'-Biphenyl]-2-Yl)Diphenylphosphine adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity for catalytic applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.