Description

2-(Diphenylphosphino)-2',4',6'-Triisopropylbiphenyl is a specialized, sterically hindered phosphine ligand widely recognized for its efficacy in transition metal catalysis. This compound matters because it enables highly efficient and selective cross-coupling reactions, which are fundamental to constructing complex organic molecules in advanced chemical synthesis. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require robust catalytic systems for challenging transformations.

Application

• As a key ligand in Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions for C-C and C-N bond formation.
• Catalyst component in the synthesis of active pharmaceutical ingredients (APIs) and complex drug intermediates.
• Enabling technology for agrochemical research, particularly in creating novel herbicides and fungicides.
• Use in academic and industrial R&D for developing new catalytic methodologies.
• Facilitating polymer and material science applications, including the synthesis of conjugated polymers.
• Supporting fine chemical production where high selectivity and yield are critical.

Basic Information

Product Name	2-(Diphenylphosphino)-2',4',6'-Triisopropylbiphenyl
CAS No.	819867-23-7
Molecular Formula	C36H43P
Molecular Weight	506.70 g/mol
Synonyms	XPhos; 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (common misnomer for related ligand); 2-(Diphenylphosphino)-2',4',6'-triisopropyl-1,1'-biphenyl; DavePhos (common trade name for related ligand class); Biarylphosphine ligand; Buchwald ligand; Triisopropylbiphenylphosphine ligand; t-BuXPhos (related ligand, often confused)
EINECS	Contact for details

Quality Control

Our production of 2-(Diphenylphosphino)-2',4',6'-Triisopropylbiphenyl adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for catalytic applications. Each lot is characterized by advanced analytical techniques, including NMR and HPLC, to confirm identity and assay. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, containers should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.