Description

2-(Di-tert-Butylphosphino)-2',6'-Dimethoxybiphenyl is a specialized, high-value organophosphorus ligand. This compound matters for its critical role in facilitating challenging cross-coupling reactions, enabling the synthesis of complex pharmaceutical intermediates and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for catalyst development and scale-up.

Application

• Catalyst Ligand in Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and related C-N, C-O, and C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective production of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific stereochemistry.
• Material Science: Facilitates the creation of conjugated polymers and organic electronic materials through controlled polymerization.
• Process Chemistry & Scale-Up: Employed in optimizing manufacturing routes for high-value compounds, improving yield and selectivity.
• Academic & Industrial Research: A valuable tool for methodology development in synthetic organic chemistry laboratories.

Basic Information

Product Name	2-(Di-tert-Butylphosphino)-2',6'-Dimethoxybiphenyl
CAS No.	819867-21-5
Molecular Formula	C26H39O2P
Molecular Weight	414.56 g/mol
Synonyms	2-(Di-tert-butylphosphino)-2',6'-dimethoxy-1,1'-biphenyl; Di-tert-butyl(2',6'-dimethoxybiphenyl-2-yl)phosphine; DavePhos; RuPhos Precursor Ligand; SPhos Analog; Buchwald Ligand; t-BuDavePhos; 2-(Di-tert-butylphosphanyl)-2',6'-dimethoxybiphenyl
EINECS	Contact for details

Quality Control

Our production of 2-(Di-tert-Butylphosphino)-2',6'-Dimethoxybiphenyl adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by NMR (1H, 13C, 31P), HPLC, and elemental analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided. Keep the container in a cool, dry, well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.