Description

(S)-7,7'-Bis[Di(p-Methylphenyl)Phosphino]-1,1'-Spirobiindane is a high-purity, chiral bisphosphine ligand essential for creating highly selective asymmetric catalytic systems. Its value lies in enabling the synthesis of enantiomerically pure compounds, which are critical for pharmaceuticals and advanced materials. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for developing new synthetic routes and optimizing existing ones.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Catalysis: Used in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings to construct complex chiral molecules.
• Pharmaceutical Process Development: Critical for scaling up the production of active pharmaceutical ingredients (APIs) with high enantiomeric excess (ee).
• Agrochemical Synthesis: Employed in the creation of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Facilitates the production of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial Research: A valuable tool for methodology development in organic synthesis and catalysis research.

Basic Information

Product Name	(S)-7,7'-Bis[Di(p-Methylphenyl)Phosphino]-1,1'-Spirobiindane
CAS No.	817176-80-0
Molecular Formula	C55H48P2
Molecular Weight	771.91 g/mol
Synonyms	(S)-SIPHOS-PE; (S)-7,7'-Bis(di-p-tolylphosphino)-1,1'-spirobiindane; (S)-DTB-SIPHOS; (S)-Spiro-SIPHOS; (S)-Bisphosphine Ligand SIPHOS-PE; (S)-1,1'-Spirobiindane-7,7'-diylbis(di-p-tolylphosphine); (S)-Bis(di-4-methylphenylphosphino)-1,1'-spirobiindane; (S)-SIPHOS Ligand
EINECS	Contact for details

Quality Control

Our (S)-7,7'-Bis[Di(p-Methylphenyl)Phosphino]-1,1'-Spirobiindane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is analyzed to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and degradation. Keep the container in a cool, dry, well-ventilated place away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.