Description

L-Serine-2,3-13C2 is a stable isotope-labeled analog of the essential amino acid L-serine, specifically enriched with carbon-13 at the 2 and 3 positions. This high-purity labeled compound is critical for advanced research and development, enabling precise metabolic pathway tracing and quantitative analysis in complex biological systems. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions engaged in metabolomics, drug discovery, and clinical biomarker studies.

Application

• Metabolic Flux Analysis (MFA): As an internal standard for quantifying serine metabolism and related pathways (e.g., glycine, one-carbon metabolism) in cell cultures and tissues.
• Biomarker Discovery & Clinical Research: Used in mass spectrometry-based assays for the accurate detection and quantification of serine in biological fluids for disease state profiling.
• Pharmaceutical R&D: Serves as a labeled precursor in the synthesis of isotopically labeled drug candidates or metabolites for pharmacokinetic and pharmacodynamic (PK/PD) studies.
• Nutritional Science: Employed in tracer studies to investigate amino acid utilization, protein synthesis, and metabolic disorders.
• NMR Spectroscopy: Provides a distinct signal for structural elucidation and dynamic studies of proteins and peptides where serine residues are involved.
• Quality Control Reference Standard: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating methods in regulatory environments.

Basic Information

Product Name	L-Serine-2,3-13C2
CAS No.	89232-78-0
Molecular Formula	C13H7NO3
Molecular Weight	107.06 (for 13C2 isotopologue)
Synonyms	(2S)-2-Amino-3-hydroxy(13C2)propanoic acid; L-Serine-2,3-13C2; Serine-2,3-13C2; (S)-Serine-2,3-13C2; Isotopic L-Serine; 13C Labeled L-Serine; L-2-Amino-3-hydroxypropionic acid-2,3-13C2; [2,3-13C2]-L-Serine
EINECS	Contact for details

Quality Control

Our L-Serine-2,3-13C2 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, meeting the rigorous demands of research and regulatory applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, chiral purity, and analytical results from techniques such as NMR, HPLC, and MS. We adhere to cGMP principles where applicable, and our quality commitment ensures reliable, lot-to-lot consistency for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.